Nordic network addressing the a antimicrobial resistance (AMR) challenge and mapping AMR-related research in the Nordic countries

The goal of the current application is to broaden and develop the Nordic networks, as a natural basis for further applications to EU/JPI-AMR, the public sector and NGOs. 

WP1: BASIC ASPECTS AND NOVEL DRUG TARGETS

WP1.1. Innovative therapeutics

We will develop and study effects of new drugs and examine the use of old and revived antibiotics. Novel screening methods for chemical libraries in search of new classes of antibiotics will be employed.

WP1.2. Novel barriers to horizontal gene transfer and evolution of resistance

We will focus mainly on transformation as an important mechanism for horizontal gene transfer (HGT) of antibiotic resistance genes between “contemporary” bacteria. Such antibiotic resistance is polygenic in nature and transposon-linked sequencing (Tn-seq) technology provides a unique methodology to identify genes that mediate AMR and can represent novel drug targets.

WP2 CLINICAL RESEARCH APPROACHES TO COMBAT AMR

WP2.1. Surveillance and clinical trials

 We will conduct surveillance projects for better detection and characterization of extended-spectrum beta-lactamases (ESBL) in Gram-negative bacteria. Active surveillance in all patients will contribute to a more efficient detection of ESBL-producing Enterobacteriaceae as well as other relevant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE).

WP2.2 Novel infection control interventions

We will do a systematic characterization of the microbiota composition in selected patient groups and healthy controls at the genomic level, and follow development of acquisition or failure of eradication, infection and nosocomial transmission. Defining microbiota characteristics will allow interventions targeted at infection prevention in the individual patient (personalized medicine) and infection control at the hospital level.

THE NORDIC AMR RESEARCH NETWORK

All WPs will profit to include representatives from several Nordic countries when seeking other international collaborators, being a very attractive partner from a Nordic “stronghold niche” towards other "high-prevalent" European and global partners. The network will be established by invitation to 1-2 workshops. A call will be conveyed through relevant Nordic and national bodies including research councils, public health institutes, NGO’s ( REACT), existing informal networks etc. The workshops will be professionally facilitated, addressing networking and mapping of AMR scientists and their activities facilitating coordination. The outcome will be a new Nordic network addressing AMR, publicly available information on an interactive website and joint efforts to generate further funding for continued development of the network will be planned.

Facts about the project
Project manager

Oslo University Hospital
TTA Consortium